Answer: Your best bet would probably be to use a special type of Bacillus thuringiensis (known as B.t.), a natural insecticide, that was developed for this pest. Note that most B.t. products are for caterpillars and will not control the Colorado Potato Beetle. However, the "San Diego" strain of B.t. will control them. It is sold under several brand names including M-One and M-Trak which is sold by: Gardens Alive, 5100 Schenley Place, Lawrenceburg, IN 47025, (812) 537-8650.
Another organic option is to use a rotenone/pyrethrin spray labeled for potatoes.
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