Answer: If the holly is healthy you'll probably have to deal with suckers from the roots after the shrub is cut down. You can avoid this by digging out the roots. You'll want to dig them out anyway if you plan to plant something else in the spot it now occupies. If the thought of a few sprouts doesn't alarm you, just cut the holly down at ground level. Anything that sprouts up can be cut back. Eventually the roots will run out of energy and quit producing shoots.
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