Follow the label carefully as it is the final authority on the use of any spray product. However, once in the spring should be sufficient. Then you may want to see if another fall application is needed. Do not also use weed and feed. To really get to the bottom of your weed problem I suggest you take some examples of the various weeds to your County Extension Office for proper identification. Then they would then be able to recommend an appropriate, labeled herbicide product for you to use which would be the most effective against the particular types of weeds you have. They would also be able to recommend the proper timing which is critical to effective control.
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