Answer: There are a number of different diseases that can affect holly, and sometimes winter damage can also cause foliage symptoms the following spring. I would suggest you work with your local county extension to determine what is causing the problem(s) and then knowing that, determine how to proceed. If it is something that requires a chemical control they will have the most up to date recommendations on what to use and how/when is best to apply it. They may appreciate a photo of the overall plant as well as closeups of the affected leaves, and/or a freshly cut twig and foliage sample enclosed in a clear plastic bag -- and kept cool so it stays fresh -- to look at. I hope it is nothing too serious.
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