That is a challenge indeed! The best way to start is by keeping the soil surface covered with mulch. This prevents light from reaching the soil and greatly reduces weeds that are coming from seeds. If perennial weeds are invading from adjacent areas such as a lawn you can install edging that goes down into the soil several inches deep and then keep the boundary line trimmed to prevent a weed from "crawling over" the edging. When weeds invade they can be killed with an appropriate product. There are selective grass killers that don't harm most broadleaf plants such as the shrubs and flowerers in your beds. Two ingredients to look for are sethoxydim and fluazifop. There are also non selective weed killers that can kill most any plants you get them on. Glyphosate (one brand is Roundup) is an example of a non-selective product. You will need to apply these to the weeds with a wiper type applicator to avoid any contact with desirable plants in the beds.
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