Answer: Ladybugs are considered beneficial, so there's no insecticide registered for use against them. If it's any comfort to know, the invaders are most likely the Asian imported kind and they're doing what comes naturally. Native ladybugs hibernate on tree stumps in the foothills. When the weather warms, they disperse. The imported ladybugs are cliff-dwellers and look for a high and dry area to hibernate. Sometimes they'll congregate under the eaves of buildings. As the outside temperature drops they are drawn toward heat sources and will squeeze and push each other through tiny openings. That's how they end up in the walls and attics of homes. Warm household temperatures make them think it's spring, so they wake and begin to dispurse. You're likely to find them flying toward windows and doors, dropping from the ceiling and crawling on floors and walls. Sweep or vacuum them up and send them outdoors. Next spring inspect the siding of your parent's home and seal any openings you find, in an effort to stop next year's invasion.
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