I'm afraid it would. I don't use any weed "killers" in my beds, just pre-emergents.I tried to "wipe' some Roundup on quackgrass in a bed once, and it turned the grass yellow after 1 application, and I believe a 2nd would have killed it, but it also seemed to bother the iris that were next to it( fumes, I guess). So I went back to just digging it out!...Arlyn