My Hooker's Orchid Cactus (Epiphyllum hookeri) has set three fruits this year. Does anyone know for sure if they are safe for humans to eat??

Yes, it is ... but often bland and certainly not large.

According to this site they are edible but not that tasty and very seedy. Also take a long time for the fruit to ripen. http://www.theamateursdigest.c...

Thanks for the link...very informative article. My fruits already feel somewhat soft, which is a bit of a surprise as they haven't been there that long. They sure colorful