I don't mind self-seeding (it's usually not too hard to scrape out the seedlings), but I am getting a bit wary of miniature comfrey which is starting to "run" and is pretty vigorous in damp soil. It's a nice groundcover (smothers out weeds beautifully), and the worst thing about it is that it is so hard for ME to tear it out. I always think "maybe I can transplant some of it...." instead of just getting rid of the excess. So it's more "emotionally invasive" that actually physically invasive...
When my foxgloves set seed this year, I let them stand and I have a whole new patch of seedlings starting up. I also cut some of the stems with ripe seeds and laid them in other spots in the garden...hoping to see seedlings there too.