I haven't tried this, but it might be better than one-by-one. Or completely silly. I'm trying for a cotton gin without teeth.
Find something rubbery with a little "tackiness" or high friction, like a hard mouse pad or sink-drainer mat or the no-slip pad in a bathtub. I have some left-over pieces of anti-static matting that would be ideal.
Cut two pieces of the rubbery stuff - one 6" long and 1-2" thin, with one long edge clean and straight.
The other piece needs to have one edge (perhaps a 2" short edge) clean and straight.
Use the 6" piece to hold down some seeds with fluff sticking out past the 6" edge of the rubbery mat.
The tackiness of the mat should help to grip the seeds.
(I assume the seed is thicker than the fluff).
Now use the other piece to pull off the fluff that sticks out:
- match the two straight edges together, small piece on top of the fluff and long piece holding seeds down
- keeping pressure on smaller piece to keep friction on the fluff. drag the smaller piece away and try to pull the fluff with it.
- maybe rapidly "pat-rub, pat-rub" to pluck fluff away from seeds.
Maybe you can just set the 6" piece over a pile of seeds and use the other piece to pull fluff off seeds, or seeds off fluff, depending on what sticks out. Then slide the 6" piece backwards, gradually letting seeds and fluff emerge from under it so you can pull at them with the smaller piece.
Repeat dozens of times, holding many seeds in place with one piece of mat, and then pulling the fluff off with the other piece.
It might have to be on a hard, slippery surface like a china plate so the fluff will slide away.
If you do try it, please let me know if it works! Apologies in advance if it's useless.