I have never used bone. If I had a source, I would certainly see how it worked. Unless the driftwood must remain as-is, you can always cut it to get it to a more manageable size. I cut, shave, and/or sand practically every mount I use. I also like to finish one side of the wood and coat that side with a durable layer of epoxy. I can't do that with some pieces of driftwood though.
Good luck. I am sure you'll come up with something that will look great.
