A few years ago I saw Dragon Fruit growing at the Coastal Botanical Gardens in Savannah where they research cold tolerant fruits. They had some in a GH and others were in the open but would be covered with a temporary cover when necessary. The plants were like huge thorny vines and they had them growing on 6" x 6" posts with heavy wire strung between them. We got to taste the fruit and it was very sweet but those plants need a lot of real estate.