Hi there,
I grow Asclepias variegata myself, and it grows in the wild here in MS commonly enough. I have 2 plants happily growing in 3 gal. pots in well drained potting mix. Here in MS, this species grows just fine in our acidic clay soils.
"That land is a community is the basic concept of ecology, but that land is to be loved and respected is an extension of ethics." — Aldo Leopold