The succulent Euphorbias taste pretty horrible to the squirrels, bunnies, and mice that snack on succulents here... one try and they don't come back for more. I have been planting a bunch of them for that reason. Maybe the Euphorbias would be iguana-proof too. Dyckias tend to be pretty well armed (those marginal spines) but maybe when the animals are hungry enough, they don't care. I've never seen them try one here, when they have juicy Aeoniums and aloes to eat instead.