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May 14, 2024 5:35 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
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COVID patient testing, isolation of sick staff cut in-hospital viral spread, modeling study suggests
Mary Van Beusekom, MS Today at 1:33 p.m.
COVID-19

Interventions such as testing patients for COVID-19 on admission, isolation of ill healthcare workers (HCWs), and universal HCW masking from March 2020 to July 2022 significantly reduced SARS-CoV-2 transmission among patients and staff in UK hospitals, suggests a simulation study led by UK Health Security Agency researchers in London.

The findings were published last week in BMC Infectious Diseases.

The scientists used an individual-based model of in-hospital SARS-CoV-2 spread and a panel of infection-prevention experts to estimate the effectiveness of disease-mitigation measures during the first 2 years of the COVID-19 pandemic. The study period spanned the predominance of different viral variants and the availability of different vaccines and doses.

"Model parameters and associated uncertainty were derived using national and local data, literature review and formal elicitation of expert opinion," the study authors wrote. "We simulated scenarios to explore how many nosocomial [hospital-related] infections might have been seen in patients and HCWs if interventions had not been implemented."

Several potential confounding factors
Results of the simulation suggest that, without COVID-19 testing at hospital admission, other infection-prevention protocols, and limits on occupancy and visitors, twice as many patients could have been infected in the first 2 years of the pandemic.

"Testing and cohorting of patients and isolation of HCWs were the most important interventions for reducing transmission to patients and HCWs preventing up to 34% (30–40%) of infections," the researchers wrote. "We also identified a significant role for masking, with universal masking being more impactful than masking around patients alone (40% (30–52%) vs 17% (14–20%) reduction)."

They cautioned, however, that their study focused on the overall impact of masking but didn't distinguish between the use of respirators or surgical masks. Also, it assumed total compliance with measures such as testing and isolation and didn't consider individual HCW differences in risk of infection when outside the hospital.

Importance of high levels of compliance
The infection-prevention measures had the greatest effect during times of limited immunity (beginning of the pandemic and during the Omicron variant surge) and were least effective during times of high immunity from COVID-19 vaccination and previous infection.

These results highlight the importance of maintaining high levels of compliance to infection prevention and control measures in hospitals and have important implications as hospitals prepare for a surge in demand due to emerging winter pressures and COVID-19.
"Model findings suggest that collectively the interventions introduced over the SARS-CoV-2 pandemic in England averted 400,000 (240,000 – 500,000) infections in inpatients and 410,000 (370,000 – 450,000) HCW infections," the researchers wrote.

The authors said that the findings point to a role for limited patient visitation during times of high community prevalence.

"These results highlight the importance of maintaining high levels of compliance to infection prevention and control measures in hospitals and have important implications as hospitals prepare for a surge in demand due to emerging winter pressures and COVID-19," they concluded.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 14, 2024 5:36 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
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FDA warns of false results from Cue Health COVID tests
News brief Today at 3:35 p.m.
Lisa Schnirring
Topics COVID-19

The Food and Drug Administration (FDA) yesterday urged home test users, caregivers, and health providers not to use Cue Health's COVID-19 tests for home and over-the-counter use and its test for point-of-care settings due to an increased risk of false results.

nasal swabb
Banc d'Imatges Infermeres, Ariadna Creus i Àngel García / Flickr cc


The two tests, which detect nucleic acid from SARS-CoV-2, are identical except for their emergency use authorizations (EUAs), according to the company.

The FDA said it issued a warning letter to the company on May 10 after an inspection revealed that Cue Health had made changes to the tests that reduced the reliability of the tests to detect SARS-CoV-2. The point-of-care test had received an EUA on June 10, 2020, and the home test was granted an EUA on March 5, 2021.

Consumers and healthcare providers who have Cue Health tests should dispose of them in the household or general trash, the FDA said. It added that health providers should consider retesting patients using a different test if they suspect an inaccurate result from a Cue Health test.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 14, 2024 5:37 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
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CDC launches new influenza A wastewater dashboard, states report more H5N1 in dairy herds
Lisa Schnirring Today at 3:54 p.m.
Avian Influenza (Bird Flu)

The Centers for Disease Control and Prevention (CDC) today unveiled a new influenza A wastewater tracker, part of its surveillance for H5N1 avian influenza, as three states reported more detections in dairy herds.

With the strong possibility that dairy cows can be spreading H5N1 asymptomatically and because testing in dairy herds has been spotty with delays in reporting, virologists and public health officials are looking at other ways—including wastewater testing—to gain better visibility on where H5N1 might be spreading.

Very few locations at the high level, but worth a closer look
The CDC launched the influenza A wastewater dashboard on its H5N1 monitoring page. It emphasized that current wastewater monitoring through its National Wastewater Surveillance System, which has more than 600 sites, doesn't distinguish the influenza A subtype or determine the source of the virus. Influenza viruses can come from humans, animals, or contaminated products such as milk.

In its interactive map, the CDC categorizes current influenza A levels compared to levels seen at the same time during the 2023-2024 season. When levels are at the 80th percentile or higher, the CDC said it works with state and local partners to better understand factors that could be contributing to the levels.

Over the 2 most recent weeks, 230 sites from 34 states met the data reporting criteria, and three sites in three states were at the high level: Kansas (Saline County), Florida (Pinellas County), and Illinois (Kane County).

Marc Johnson, PhD, a virologist at the University of Missouri who has developed a probe to detect H5 in wastewater, said on X today that the CDC's dashboard is nice and that he's glad they're posting the information.

"I don't necessarily think that there needs to be a parallel H5 test run on every sample, but testing samples that are suspiciously high for it seems appropriate," he said.

Brian Wasik, PhD, a molecular biologist who is a research associate at the Baker Institute for Animal Health at Cornell University in New York, said on X that the CDC's dashboard will help shed light on baselines and longitudinal trends and what targets to explore.

H5N1 detected in 4 more dairy herds
In other developments, the US Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) today reported four more H5N1 detections in dairy herds, raising the total to 46.

All are from already affected states. Two are from Michigan, with Texas and Idaho each reporting one more affected herd.

Also, APHIS reported three more H5N1 detections involving wild birds, two of them from counties where dairy herds have been affected. Detections in Michigan (Ionia County) and Idaho (Cassia County) involved agency-harvested birds, a rock dove and a black-billed magpie, respectively.

The other is a red-tailed hawk found dead in New York's Dutchess County. APHIS said all of the detections involve the Eurasian H5N1 subtype.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 14, 2024 11:21 PM CST
North Central Massachusetts (N (Zone 5b)
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This was in the rolling credits (credits at the end) of a TV show I just watched! It makes sense, but I'm filing it under the heading, Things I had no idea about.

Thumb of 2024-05-15/joannakat/a22cfa
You don't kick walls down, you pull the nails out and let them fall.
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May 15, 2024 4:51 AM CST
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Well, I'll be.... It does make sense.
Minds are like parachutes; they work better when they are open.
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May 15, 2024 7:20 AM CST
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I've seen similar credits on quite a few shows. I suspect the film and TV industry is one of the few that takes COVID seriously.
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May 15, 2024 10:51 AM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
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COVID Still Deadlier Than the Flu -- But the Gap Is Narrowing
— VA study finds 35% higher mortality rate in hospitalized patients

https://www.medpagetoday.com/i...
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 15, 2024 4:26 PM CST
Name: Sally
central Maryland (Zone 7b)
See you in the funny papers!
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I take a dimmer view of the film industry- there are so many folks in film credits, are they all really skilled at those tasks? Or friend of friends let's hire them and give them some tasks.. a manager, scheduler, and a coordinator? What's a runner? . If only they'd all take firearms safety so seriously. (Rust shooting incident - what excuse is there to even have real firearms on a movie set when you can digitally add the effects?)
Plant it and they will come.
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May 15, 2024 6:29 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
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Study: Before vaccines, 44% of COVID-19 patients in ICU died
Stephanie Soucheray, MA Today at 2:40 p.m.
COVID-19

A new analysis of pre-vaccine data from scientists at the Centers for Disease Control and Prevention (CDC) shows that 18% of hospitalized patients and 44% of those admitted to an intensive care unit (ICU) for COVID-19 died, with wide variations among different groups.

The study was published yesterday in Emerging Infectious Diseases and is based on 2,479,423 cases from 21 jurisdictions with hospitalization information reported to the CDC from May 1, 2020, to December 1, 2020, to create a hospitalization dataset. The authors also analyzed 4,708,444 cases from 22 jurisdictions for a death dataset during the same time frame. The case-hospitalization dataset covers 25.5% of the US population, and the case-fatality dataset covers 43.7% of the US population, the authors said.

Before the mid-December 2020 introduction of COVID-19 vaccines, the pandemic caused approximately 480,000 hospitalizations, and 350,000 deaths in the United States.

"Few precise estimates of hospitalization and mortality rates exist in the COVID-19–naive population in the United States, especially among demographic and clinical subgroups," the authors said.

Few precise estimates of hospitalization and mortality rates exist in the COVID-19–naive population in the United States.
26% of those 75 and older hospitalized
The overall case-hospitalization rate among patients was 5.7%, and the rate by sex was 6.2% for male and 5.2% for female. Hospitalization rates were lowest for children ages 5 to 14 (0.6%), and highest in case-patients 75 years and older (25.9%).

When looking at racial and ethnic demographics, the highest case-hospitalization rates were among African American or Black (14.0%) and Asian or Pacific Islander (11.2%) patients. White patients had the lowest rate (6.8%).

In the deaths dataset, the overall case-fatality rate was 1.7%. The lowest death rates were seen in infants and young children (0.05% for infants and 0.01% for children 1 to 14 years of age). Ten infants died in the study period.

Case-fatality rates increased steadily with age. The rate was 4.7% in patients 65 to 74 years old, 12.0% in those 75 to 84, and 23.6% in people 85 and older.

Case-fatality rates for female patients were lower than or equal to those for male patients in every age-group except infants, the authors said.

Asian or Pacific Islanders had the highest crude mortality rate (3.0%), followed by Black and African Americans (2.8%).

The fatality rate was 0.6% in people who were not hospitalized. The rate was 17.6% among all people who were hospitalized and 44.2% in those admitted to an ICU.

Age biggest predictor of death
"Age was a primary driver of SARS-CoV-2 hospitalization and death; rates had a U-shaped curve, being higher in infants, lowest in children 5 to 14 years of age, and highest among persons >65 years of age, confirming previous reports, " the authors concluded.

The analysis confirmed prior studies that have shown a nearly 50% mortality rate for ICU patients early in the pandemic. Moreover, the authors said, the findings present a baseline of data for future comparisons.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 15, 2024 6:30 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
https://www.cidrap.umn.edu/avi...

USDA confirms 3 more H5N1 outbreaks in dairy herds
News brief Today at 3:01 p.m.
Lisa Schnirring
Topics Avian Influenza (Bird Flu)

The US Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) today reported 3 more H5N1 avian flu outbreaks in dairy herds, raising the total to 49 in nine states.

waiting for milking
Morten Just/Flickr cc
Of the 3 newly reported events, 2 are in Michigan and 1 is in Idaho. Michigan now has 14 outbreaks, the most of any state, and Idaho has 5 affected herds.

A line list from the Michigan Department of Agriculture and Rural Development (MDARD) suggests that the latest detections are in Clinton and Gratiot counties. So far, H5N1 outbreaks have struck dairy herds in nine of the state's counties.

Tests on Canadian milk negative for H5N1 fragments
Given the H5N1 avian flu outbreaks in US dairy herds, Canada's government said yesterday that proactive monitoring of Canadian milk samples has turned up no evidence of the virus.

The testing was conducted by the Canadian Food Inspection Agency (CFIA) in collaboration with the Public Health Agency of Canada and Health Canada.

CFIA labs assessed 142 retail milk samples using polymerase chain reaction (PCR) testing, and all were negative. The PCR method can detect fragments of the virus, but it isn't able gauge the presence of live virus.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 15, 2024 7:40 PM CST
North Central Massachusetts (N (Zone 5b)
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sallyg said: I take a dimmer view of the film industry- there are so many folks in film credits, are they all really skilled at those tasks? Or friend of friends let's hire them and give them some tasks.. a manager, scheduler, and a coordinator? What's a runner? . If only they'd all take firearms safety so seriously. (Rust shooting incident - what excuse is there to even have real firearms on a movie set when you can digitally add the effects?)


A runner is an everything-person on any given set. They're highly skilled and responsible for a LOT. They are on set before anyone else, and leave after everyone else. They're also called Production Assistants. A lot of people start there and work their way up. Or work their way up to PA.

Unions are strong in TV and movies, and they take a lot of care to make sure people are skilled for their jobs. The firearm incident from Rust was horrible and it shouldn't have happened. I think the most dangerous job in TV and movies is stunt person though.

Personally, I'm extremely happy to see them taking COVID so seriously. If I were to criticize the industry for anything, it would be related to sexual harassment and abuse. Harvey Weinstein and the like.
You don't kick walls down, you pull the nails out and let them fall.
AKA Joey.
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May 17, 2024 3:02 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
https://www.cidrap.umn.edu/cov...

EPISODE 157 OSTERHOLM UPDATE
Episode 157: Lungs & Udders
Dr. Osterholm

May 16, 2024
In "Lungs & Udders," Dr. Osterholm provides updates on H5N1 influenza, COVID-19, and mpox. He also shares his thoughts on a recent WHO report about airborne transmission and a study on the use of a diabetes drug to treat COVID-19.

Airborne pathogens: controlling words won't control transmission (Greenhalgh et al., The Lancet)
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As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 17, 2024 3:04 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
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https://www.cidrap.umn.edu/avi...

USDA experiments suggest H5N1 not viable in properly cooked ground beef
Lisa Schnirring May 16, 2024
Avian Influenza (Bird Flu)

In an update today on food safety testing in light of H5N1 avian flu detections in some dairy cattle, the US Department of Agriculture (USDA) said that inoculation of ground beef patties with a virus surrogate and cooking them to medium or well inactivated the virus.

In other developments, federal officials during the same briefing announced more than $22.2 million in funding for efforts to control and respond to animal disease outbreaks, including $6 million for the National Animal Health Laboratory Network, which has played a key role in testing samples from potentially infected herds.

No virus in medium or well-done burgers
Eric Deeble, DVM, the USDA's acting senior adviser for highly pathogenic avian influenza, said that, as part of the department's food safety testing, it wanted to determine what ground beef cooking temperatures could kill H5N1.

Though the virus hasn't been detected in beef cattle, some dairy cattle are used in the production of ground beef. Earlier this month, PCR testing by USDA scientists on retail ground beef samples found no traces of H5N1.

Researchers inoculated the ground beef patties with high levels of an H5N1 surrogate virus, then cooked them to different internal temperatures. Deeble said no virus was found when the beef was cooked to 145°F internal temperature (medium) or 160°F (well done).

When the virus-laden beef patties were cooked to 120°F degrees (rare), however, the tests found evidence of the virus, but at much reduced levels, he said.

Deeble said there are no recommended changes in safe cooking practices and that the longstanding USDA Food Safety and Inspection Service (FSIS) advice is to cook beef patties to an internal temperature of 160°F.

In other food safety tests, USDA scientists are testing whole-muscle cuts for any evidence of H5N1, and he said results are expected next week.

Boost for animal disease response
Regarding the funding boost for NAHLN labs, there are no concerns about testing capacity, but the infusion will build on existing capacity and add more resources, Deeble said. Some labs need updated equipment, and some of the funding will target research projects within the labs that are aimed at expanding testing methods.

Of the more than $22.2 million announced today to boost animal disease efforts, $16.2 million will target 74 projects to advance animal disease preparedness, such as helping states develop plans and practice quickly controlling animal disease outbreaks.

In addition, $1 million is earmarked for emergency preparedness, and $5 million will go directly to labs for capacity building.

Outbreak trajectory uncertain
USDA officials today said they wouldn't speculate on the current trajectory of the outbreaks or if activity has peaked.

Deeble said, however, that the lack of recent spread beyond the nine currently affected states may be partly due to the federal rule that requires testing for dairy cows before movement between states.

Meanwhile, Nirav Shah, JD, MD, principal deputy director for the Centers for Disease Control and Prevention (CDC), told reporters that although current findings from the CDC's new influenza A wastewater dashboard are reassuring, the investigation is ongoing. "There's a lot more to be done."

The dashboard, unveiled 2 days ago on the CDC's H5N1 surveillance page, found that, over the past 2 weeks, there were only 3 sites in the high category among 230 that met data reporting criteria. The sites are in Kansas, Florida, and Illinois.

Little success testing farm workers
Regarding epidemiologic and scientific investigations, federal officials last week announced—as part of new support for farms and the outbreak response—a $75 financial incentive for farm workers at affected dairy farms to be tested. Shah said so far the CDC hasn't identified any workers who are willing to participate.

He added that the CDC is eager to conduct testing to answer key questions, such as which farm jobs pose the highest risk to workers. There are no plans to add a testing requirement, Shah said. "We would like to do this in voluntary cooperation with farms and farm workers."

Federal officials said they were aware of anecdotal reports that some proponents of drinking raw milk are claiming that drinking H5N1-contaminated milk will boost immunity against the virus. Deeble said the USDA is not aware of any raw milk sold from any of the known outbreak farms. He added that the only way to protect against H5N1 infection from milk is to avoid drinking raw milk.

Even before the H5N1 outbreak in dairy cows was first detected in late March, federal health agencies have had a longstanding recommendation against drinking raw milk because of potential contamination with pathogens.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 17, 2024 3:05 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
https://www.cidrap.umn.edu/cov...

COVID-19 linked to increased preterm birth, other problems in pregnancy
News brief May 16, 2024
Stephanie Soucheray, MA
Topics COVID-19

Findings from a large study in California, which distinguished the COVID-19 pandemic period from individual SARS-CoV-2 infections, suggest that SARS-CoV-2 infection is tied to increased preterm birth (PTB), high blood pressure during pregnancy, and severe maternal morbidity. The study is published as a research letter in JAMA Network Open.

Researchers looked at live birth data from California hospital discharge records for 2019 to 2020. They compared pregnant women with COVID-19 in 2020, pregnant women without COVID-19 in 2020, and prepandemic pregnant women in 2019.

Overall, parents with COVID-19 infections were more likely to be Hispanic, have lower education, receive public insurance, and live in lower income neighborhoods compared with the other groups, the authors said.

Infection tied to high blood pressure, severe outcomes
Birth outcomes noted included preterm birth (PTB), high blood during pregnancy, gestational diabetes, and severe maternal morbidity.

Compared to 2020 births without COVID-19 infections, there were higher burdens of PTB (2.8%; 95% confidence interval [CI], 2.1% to 3.5%), high blood pressure (3.3%; 95% CI, 2.4% to 4.1%), and SMM (2.3%; 95% CI, 1.9% to 2.7%) among women with COVID-19.

This study adds to understanding of the associations between COVID-19 and perinatal health in a large, diverse population.
"This study adds to understanding of the associations between COVID-19 and perinatal health in a large, diverse population by distinguishing the connections of SARS-CoV-2 infection from those of the COVID-19 pandemic period with PTB and birth parent conditions," the authors concluded.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 17, 2024 3:06 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
https://www.cidrap.umn.edu/cov...

COVID, other misinformation varies by topic, country on social media
News brief May 16, 2024
Stephanie Soucheray, MA
Topics COVID-19

PLOS One has published a study noting that the spread of COVID-related and other misinformation on social media varies by topic and by country in Europe.

The study was conducted by analyzing news activity on Twitter (now X) in France, Germany, Italy and the United Kingdom from 2019 to 2021, noting misinformation on major news topics including Brexit, coronavirus, and COVID-19 vaccines.

News sources cited were rated as either "reliable" or "questionable" based on their NewsGuard scores, which measure nine journalistic criteria, assigning outlets a reliability score out of 100.

Rate of questionable news highest in German
The authors found the United Kingdom maintained a relatively stable proportion between questionable and reliable retweets across different topics. Germany, on the other hand, had the highest ratio of questionable news retweets on each of the three topics analyzed, followed by France.

"Our findings indicated that reliable sources dominate the information landscape, but users consuming content mainly or exclusively from questionable news outlets were often present," the authors concluded.

The authors also said monitoring news consumption by country rather than continental region would be useful for any efforts looking to combat misinformation.

Monitoring the information landscape at both national and European levels is indeed crucial to understanding the state of public discourse on contentious topics.
"Monitoring the information landscape at both national and European levels is indeed crucial to understanding the state of public discourse on contentious topics and detecting the emergence of new and divisive narratives within the European context," they said.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 17, 2024 3:09 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
https://www.cidrap.umn.edu/cho...

Quick takes: Pre-exposure COVID prevention
News brief May 16, 2024
Lisa Schnirring
Topics COVID-19

Astra Zeneca today reported promising phase 3 findings its long-acting monoclonal antibody for pre-exposure prophylaxis (prevention) against COVID-19 in immunocompromised patients. The drug, called sipavibart, showed a statistically significant reduction in symptomatic COVID when compared to placebo. Also, the drug showed potential benefits that spanned evolving SARS-CoV-2 variants, given that several variants circulated over the course of the trial. The drug was well tolerated, with levels of adverse events similar in both the treatment and control groups. Astra Zeneca is currently in talks with drug regulators about possible approval or authorization pathways. In early 2023, the US Food and Drug Administration (FDA) pulled the emergency use authorization for Evusheld, an earlier pre-exposure prophylaxis monoclonal antibody, because it was unlikely to be effective against the latest SARS-CoV-2 variants.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 17, 2024 3:11 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
https://www.cidrap.umn.edu/mea...

Measles outbreak at Chicago shelter occurred mostly in unvaccinated, case study shows
Mary Van Beusekom, MS Today at 2:15 p.m.
Measles

A study published yesterday in Morbidity and Mortality Weekly Report (MMWR)details a measles outbreak that sickened 57 people at a Chicago migrant shelter this year and how a prompt and coordinated mass-vaccination campaign helped contain it.

Measles is a highly contagious respiratory virus that can cause severe complications, hospitalization, and death. In 2000, the United States declared measles eradicated, but cases still occur because of ongoing global spread and undervaccination, noted the Centers for Disease Control and Prevention (CDC)-led study team. "Receipt of 1 and 2 doses of measles vaccine is 93% and 97% effective, respectively, in preventing measles."

Since August 2022, they said, about 41,000 migrants have arrived in Chicago from the southern US border, 88% of them from Venezuela, which has seen a decline—from 96% in 2017 to 68% in 2021—in routine childhood vaccinations, including the measles vaccine.

First reported case was in 1-year-old boy
On February 22, 2024, about 12,000 people were staying in 27 temporary migrant shelters run by the city of Chicago. On that date, the largest of them—the affected shelter, called "shelter A" in the report—was housing roughly 2,100 people, with 500 or more staying in some rooms. In addition to congregate sleeping areas, the migrants shared a dining area and bathrooms.

Given the congregate nature of the setting, high transmissibility of measles, and low measles vaccination coverage among shelter residents, measles virus had the potential to spread rapidly among approximately 2,100 presumed exposed shelter residents.
The first case of the outbreak was identified in a 1-year-old boy living at the shelter. He developed a rash on February 26 and was hospitalized the next day for suspected measles.

The boy had arrived in the United States more than 5 months earlier and had received one dose of measles, mumps, and rubella (MMR) vaccine 5 weeks before symptom onset; he had not traveled recently or had a known exposure to measles. The Chicago Department of Public Health (CDPH) confirmed the infection on March 7.

"Given the congregate nature of the setting, high transmissibility of measles, and low measles vaccination coverage among shelter residents, measles virus had the potential to spread rapidly among approximately 2,100 presumed exposed shelter residents," the researchers wrote.

CDPH worked with state and local health departments, health care facilities, city agencies, and shelters on outbreak investigation and response. On March 8, CDPH began case-finding efforts and launched a mass-vaccination campaign at the shelter, vaccinating 882 residents and verifying previous vaccination for 784 over 3 days.

"These activities resulted in 93% measles vaccination coverage (defined as receipt of ≥1 recorded measles vaccine dose) by March 11," the authors said. "By May 13, a total of 57 confirmed measles cases associated with residing in or having contact with persons from shelter A had been reported."

As of May 13, CDPH had held roughly 130 mass vaccination events at 25 Chicago migrant shelters and administered about 9,500 MMR vaccine doses, prioritizing the shelters that had previously received residents from shelter A and those housing pregnant women and young children. "This strategy included additional vaccination events at shelter A beginning on March 25, with a focused second-dose vaccination campaign during April 8–10," the researchers said.

Index infection likely acquired locally
Most infections (72%) occurred in unvaccinated residents, and 28% were diagnosed in those who had received at least one measles vaccine dose at least 21 days before the first known measles exposure.

The risk for transmission within and outside of shelters can be mitigated by maintaining high MMR vaccination coverage among both established and newly arrived residents.
Fifty-two of the 57 infected people were shelter residents, while three were staff workers, and two were community members. The median patient age was 3 years. Two cases occurred among people who had lived at the affected shelter but had resettled or transferred to less-crowded shelters with private sleeping areas after March 7; no secondary cases were identified at those shelters.

Fifty-one people (89%) were hospitalized for isolation and/or measles complications, but no deaths were reported. The last known exposure at the affected shelter was April 5. As of May 13, the same measles genotype D8 sequences had been identified from 52 case specimens; the remaining 5 isolates couldn't be sequenced.

"Although persons in the community affected by this outbreak had recently arrived in the United States, the index patient's arrival in Chicago months before illness onset suggests that the disease was acquired locally," the authors concluded. "The risk for transmission within and outside of shelters can be mitigated by maintaining high MMR vaccination coverage among both established and newly arrived residents."
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 17, 2024 3:14 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
https://www.cidrap.umn.edu/cov...

Quick takes: School infection prevention, low US respiratory virus levels
News brief Today at 2:19 p.m.
Lisa Schnirring
Topics COVID-19 Influenza, General Norovirus

The US Centers for Disease Control and Prevention (CDC) today released consolidated, evidence-based guidance for preventing the spread of a host of infections in primary and secondary schools. It covers steps schools can take to curb the spread of both respiratory and stomach viruses, as well as bacterial illnesses such as strep throat. In a press release, the CDC said the goal is to maximize school attendance, and the agency said it is releasing the guidance now so that schools can use it to prepare for the 2024-25 school year. Some of the steps include reinforcing proper hand hygiene and respiratory etiquette, improving building ventilation, cleaning and sanitation when appropriate, and promoting vaccination. During outbreaks, the CDC advises schools to take a layered approach, which might include wearing masks and distancing, and screening for illnesses.
Respiratory illness activity in the United States remained low last week, with no jurisdictions reporting moderate, high, or very high levels, the CDC said today in its weekly respiratory illness snapshot, which covers COVID-19, seasonal flu, and respiratory syncytial virus (RSV). Flu test positivity declined last week, and COVID and RSV test positivity remained stable compared to the previous week. For COVID, wastewater detections of SARS-CoV-2 remained at the minimal level. And for influenza A, which the CDC is now tracking to support H5N1 avian flu monitoring, wastewater detections over the most recent 2 weeks were in the high category at four sites: two in California (San Francisco/San Mateo and Sonoma), and one each in Kansas (Saline County) and Texas (Dallas). The CDC received reports of 3 more pediatric flu deaths, raising the season's total to 167.
As Yogi Berra said, “It's tough to make predictions, especially about the future.”
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May 17, 2024 5:42 PM CST
North Central Massachusetts (N (Zone 5b)
Life & gardens: make them beautiful
Bee Lover Butterflies Garden Photography Cat Lover Million Pollinator Garden Challenge Region: Massachusetts
Region: Ukraine
crawgarden said: https://www.cidrap.umn.edu/cov...

EPISODE 157 OSTERHOLM UPDATE
Episode 157: Lungs & Udders
Dr. Osterholm

May 16, 2024
In "Lungs & Udders," Dr. Osterholm provides updates on H5N1 influenza, COVID-19, and mpox. He also shares his thoughts on a recent WHO report about airborne transmission and a study on the use of a diabetes drug to treat COVID-19.

Airborne pathogens: controlling words won't control transmission (Greenhalgh et al., The Lancet)
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If it's Ozempic, I'm going out to expose myself to COVID.
You don't kick walls down, you pull the nails out and let them fall.
AKA Joey.
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May 17, 2024 6:04 PM CST
Name: Rj
Just S of the twin cities of M (Zone 4b)
Forum moderator Million Pollinator Garden Challenge Plant Identifier Garden Ideas: Level 1
Metformin
As Yogi Berra said, “It's tough to make predictions, especially about the future.”

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