The Aloe Hercules is shedding its leaves for the year and starting to grow. I found an ant nest while inspecting today. Not sure its any issue though. Hopefully with the leaves gone it will dry out and they will move on.

Are the ants actually nesting in there, or are they cultivating some kind of bugs? That would be my concern, as in my experience heavy ant traffic on aloes is associated with pests. I can't tell what the round things in the photo are, though.

I don't see any ants in your photo, it looks like some other type of insect pest to me. Possibly aphids or scale? See if you can properly identify them.
I'd start by just washing or gently rubbing off as many as possible. Once you ID them, there may be more specific treatment.
Big aloes are my favorites, I can't grow them here but make a pilgrimage to Desert Botanical Gardens in Phoenix when I can, they have a nice collection.

Looks like scale. Scrape, spray and pray.

I would just blast it with the hose next time you water, get into all the nooks and crannies, physically remove all that stuff, and then follow up with a careful inspection the next day or whatever, maybe take more photos.