The large size of Polistes major major adults and the extensive yellow coloration on their body helps to distinguish this species from other polistines. However, the degree of yellow coloration varies, even among the members of a single nest. Very little has been published on this species.
P. major major larvae primarily feed upon caterpillars and treehoppers
P. major major and other Polistes major subspecies are preyed upon by various bird species, namely the Red-bellied Woodpecker