Hello group! I'd like to know if it is safe for me to trim this plant and start a new growth from the cutting. There is a long section where leaves have dried and browned. I'd like to cut a section out and use the greener piece to start a new plant. Is this advisable? Thanks!

Yes, anytime a plant gets out of control or un-sightly, prune away.

Yes, your Pothos cuttings will root easily in a jar of water.

To add to Daisy's advice, don't let the roots get to long before you put the cutting back into the pot, be careful not to let the soil get to dry, otherwise your cutting will die, I keep the soil moist with my pothos's

Your Pothos vines would benefit from substantial pruning. For example, the vine on the left in the photo has lost many of its leaves above where you have the cut line. Those leaves will never grow back as new growth only comes in at the tip ends of the vines. Cut the leggy vines all the way back to within a few inches of the pot so that new growth will start there. That is the only way to eliminate leggy, bare stems.

Tip cuttings with just 4-6 leaves root more readily than longer stem cuttings.

HI again. How long should it take to start new roots? Couple of weeks? Thanks!

Does that mean your cuttings have been sitting for 5 months and haven't grown roots? Yes, I would think you would see something within a couple weeks.

Noooo... It means I haven't trimmed yet! I got distracted unfortunately. Kept putting it off. Thanks for replying!

Distractions! When you do get around to it, keep the water clean and put 1 or 2 drops of Hydrogen Peroxide in every time you change the water. Hydrogen peroxide (H2O2) is unstable and when added to water, splits apart into water plus one oxygen molecule. Oxygenated water is good for rooting cuttings.

You should see some signs of root development within a couple of weeks. But it will take several weeks beyond that for the roots to be vigorous enough to be moved into potting soil. You've waited this long, give the roots as much time as they need!

Oh what great tips, thank you!! I will be very patient with the rooting process then. And yes, I thought I should change out the water from time to time. I don't have Hydrogen peroxide right now but have been using water that sits for a bit to let the chlorine evaporate.

Chlorine doesn't evaporate, but it is not a problem anyway. No need to let the water sit.

I'm seeing roots. Are they likely to get bigger / stronger if I keep waiting before potting?

"Nature does not hurry, yet everything is accomplished". Lao Tzu

Yes, they will continue to grow longer. You can pot them at any time.

I'm about to put the cuttings into soil now. Any suggestions moisture-wise? How big should the pot be? Also, I have several cuttings. Do you think I should put them into separate pots or just one?

Keep all of the cuttings together in order to get a full plant.

Use the SMALLEST pot that the cuttings will fit into. A snug fit is best. They can be up-potted later after the pot has filled with roots, but don't start with a large pot.

Use a porous potting mix that is 4 parts peat moss and 1 part perlite. Try your best to keep that potting mix damp, avoiding too dry or too wet.

That is how I get my new vines for potting new--I have these all over my house.
When the vine gets too long and for me that's about 2 feet long I cut and put in water. When roots are established, I put them in a new vase/pot themed for the room it goes in.
I have one glass and a glass pitcher filled now and no one wants them.
They are viable on a covered sunless porch--one is just doing that now.

And, this seems obvious but, I want it to drain well right? The soil needs to be dampened but the pot shouldn't sit in a pool of water...

The pot MUST have a drain hole for excess water to run through and the pot should not be left sitting in water.