I don't grow Ficus Lyratas in a nursery or greenhouse, but I do care for dozens of them in homes and office in NYC. Thus, my experience and advice varies with Ken's.
I have never had to repot one of these plants. Many things can go wrong if repotting is done unnecessarily or incorrectly. In most indoor locations, it is best to keep them in front of and close to a very sunny window. It is hard to give these plants too much light in the typical home environment. Water thoroughly as soon as the surface of the rootball feels barely moist or slightly dry. Fertilize no more than monthly at half-strength. These plants do just fine in low humidity, so misting is unnecessary unless you are trying to clean the leaves.
Initially, Lyratas do tend to lose some lower and interior leaves as they adapt to reduced indoor light. It doesn't mean the plant is dying or requires some drastic action. In time, they need to be pruned to keep them from becoming leggy.
