According to the website of dragon fruit growers here in Fallbrook, some varieties require a pollinator and some are self pollinating.
Thompson is self pollinating, but greatly benefits from a pollinator.
Undatus is self pollinating.
Polyrhizus needs a pollinator.
Guatemalan needs a pollinator.
Since mine is seed grown, i won't know whether or not I'm going to need a pollinator, but am interested in the flowers if nothing else.