Yes, spray/squirt/jet those away with water and you'll solve 95% of the problem. Come in with some insecticidal soap sprayed in between all the leaves (repeat every few days for a couple of weeks) and you may solve all of it.
I am curious if anyone has seen this pattern on soft leafed succulents.
This is Graptopetalum amethystinum. Both the mother plant and all her offspring have the same thing going on. Older leaves have these translucent spots that are permanent (until the leaf drops). It does not seem to be contagious. I have not seen this on other plants. I don't mind a few odd spots, but I am curious to know what is going on here. It appears to have nothing to do with any kind of odd chemical exposure.