as long as the cuttings are insulated in the box it's not so bad.. the cuttings that came were in plastic and Styrofoam on the outside .. will protect them like a cooler.. and overnight delivered .. if it's a limited amount you are sending I would wait longer though.. not worth taking the risk of them turning to mush.. any disease worries me.. but won't stop me.. I have had a few from reputable companies fuzz up and rot away within days of getting here.. just have to be careful with how you handle the containers you had them in.. and dispose of them quickly.. good thing is .. they are in the house for at least 2 months.. and if there is any sign of funk.. they are outta here