While I'm no expert on this, I have lost many rose bushes to rrd. When I first saw the middle picture. The center of bush stuck out like sore thumb. When seeing this in my yard a feeling of panic would set in. That was worth looking closely as I could at the photo. If you look at the growth of the entire bush this center has held onto it's orangey red longer than it should have. The stem the right of this center part is unusually thick. I also see leaf sets that are unevenly spaced in photo 3. In center photo you can see a change in leaf shape. They often become narrower and longer. Sometimes cupped and crinkled. How ever at the very least if I were to see growth such as this in my yard I would have cut that cane out. Since photo 3 shows narrowing of leaves and apparently uneven leaf spacing. The whole bush would be removed. It's just not worth it especially if rose can easily be replaced.