I actually thought about planting Prickly Pear, but as I am more interested in Tallgrass Prairie I gave up the idea. But it is quite novel to have a cactus native to the midwest.
Whenever we have slivers or the like, we put on a glob of chickweed salve and cover it with a band-aid. This somehow works.
Probably my most painful plant is the Soapweed. I was pulling some grass around the small plant and unknowingly grabbed a blade of the yucca. Yank! Sliced my hand and it felt like a nasty paper cut.