I just finished my layout and I'm happy with mostly 2 columns per row mine looks like this:
Row 2, Column 1
Watcher Notifications
Row 2, Column 2
Recent Threads
Fun Random Idea
Fun Random Plant Image
Fun Landscape Photo
Row 3, Column 1
Today's Featured Plants
Recently Popular Photos
Row 3, Column 2
Recent Database Photos
Recent Acorn Tips
Row 4, Column 1
Forums List
Row 4, Column 2
Popular Pages
Recent Database Comments
Recent Ideas
Plant Logs
Recent Landscape Photos
Row 5, Column 1
Primary Feature
Everything seems to be proportionate without any empty spaces.