Small hairy Echeveria from the Sierra Mixteca in southern Mexico with bicolored flowers (red at the base, yellow near the tip). A number of named varieties exist, sharing the same chromosome number (25). The type variety (from Puebla) has many green, incurved leaves (up to 60-170 per rosette), grows to 4-6 inches, and offsets to form raised mounds. Echeveria (Echeveria setosa var. ciliata) (Oaxaca) has fewer, shorter hairs (mostly on the margins and tips) and concave upper leaf surfaces. Echeveria (Echeveria setosa var. deminuta) (aka E. rundelii, nomen nudum; from Oaxaca) has small (~2"), clustering rosettes with blue, club-shaped leaves that have reddish tips. Echeveria (Echeveria setosa var. minor), including a clone called Echeveria (Echeveria setosa 'FO-42') (from Oaxaca), has 35-50 green or blue-green leaves, usually thinner and bluer than the type, with highly variable hairiness. Echeveria (Echeveria setosa var. oteroi) (the least common in cultivation; from Oaxaca) is most similar to var. ciliata, but has less hair (either hairless or with some marginal hairs) and fewer leaves, growing more slowly, branching less, and developing a stem over time.

This species is found in Puebla and Oaxaca. Versions of this plant have been released a few different times by the ISI as ISI 419 (1963), ISI 1197 (1980), ISI 95-28 (1995), ISI 95-29 (1995), ISI 2014-19 (2014). This species is frequently confused with other hairy Echeverias in cultivation, and some of the images above may be Woolly Rose (Echeveria 'Doris Taylor') or Echeveria 'Bombycina', two independent hybrids with pulvinata.

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