It must be near overwhelming. If you can mow or get a brush cutter to just make some paths, chances are they are not going to mow over 'that one prize wildflower' in the process. Any one thing that you see a LOT of, go ahead and cut some of it. (Even the blackberries would be helped by getting rid of old canes)
The more I think, the less I know where you would start! Any special features to work around- a creek, some mature trees..?