When the growing tip is removed, a new stem will sprout from one (and sometimes more) of the nodes, usually the one closest to the cut point. Some small cuttings for example, the one on the left is making 2 new stems:
That pic was taken just before putting those stems (and about 15 more) in a pot.
Ideally, while growing across the ground, each node will find a place to take root, which leads to each node being able to grow a new vine. When my vines are outside over summer, it takes constant vigilance to trim them often enough so that they don't take off in this way. This predictable behavior can be exploited with a long cutting, which can be coiled around the soil surface when potted, so each node is in contact with the soil, allowing roots to form at each.
I've not seen any difficult transitions, when moving water-rooted Pothos cuttings from water to pots, but usually put so many cuttings together that it might not be noticed if one did not do well, after being so soon covered with tons of new leaves from the other stems. A healthy, vigorously growing piece of Pothos should put up with about anything except being frozen or deprived of water for too long.
